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3. Kita-Sommers Profiles | Facebook
People named Kita Sommers. Katie Sommers. Lives in Denver, Colorado. View profile. Katie Somers. Lives in Oregon, Ohio. View profile. Catte De Haut Sommet.
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6. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra ...
Nov 1, 2019 · & Somers, G. R. The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. Hum. pathol. 43, 180–189 ...
Approximately 60–70% of EWSR1-negative small blue round cell sarcomas harbour a rearrangement of CIC, most commonly CIC-DUX4. CIC-DUX4 sarcoma (CDS) is an aggressive and often fatal high-grade sarcoma appearing predominantly in children and young adults. Although cell lines and their xenograft models are essential tools for basic research and development of antitumour drugs, few cell lines currently exist for CDS. We successfully established a novel human CDS cell line designated Kitra-SRS and developed orthotopic tumour xenografts in nude mice. The CIC-DUX4 fusion gene in Kitra-SRS cells was generated by t(12;19) complex chromosomal rearrangements with an insertion of a chromosome segment including a DUX4 pseudogene component. Kitra-SRS xenografts were histologically similar to the original tumour and exhibited metastatic potential to the lungs. Kitra-SRS cells displayed autocrine activation of the insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1R) pathway. Accordingly, treatment with the IGF-1R inhibitor, linsitinib, attenuated Kitra-SRS cell growth and IGF-1-induced activation of IGF-1R/AKT signalling both in vitro and in vivo. Furthermore, upon screening 1134 FDA-approved drugs, the responses of Kitra-SRS cells to anticancer drugs appeared to reflect those of the primary tumour. Our model will be a useful modality for investigating the molecular pathology and therapy of CDS.
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8. Top 7 Kitra Somers Quotes - Quotestats.com
Kitra somers quotes. Seth Rogen: For me to act natural and real but also try to be funny.
Kitra somers quotes. Seth Rogen: For me to act natural and real but also try to be funny
9. kitra somers Kitra Somers Sensualist Extraordinaire on Twitter - Telegraph
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10. Somers HS Junior Goes Above and Beyond for Special Performance
To Anthony Fusco's knowledge, the baseline for a CAS, or creativity, activity and service project, is typically a month. A requirement of the International ...
To Anthony Fusco’s knowledge, the baseline for a CAS, or creativity, activity and service project, is typically a month. A requirement of the International Baccalaureate Diploma, the projects are designed to be ongoing and collaborative and force the student to encounter experiences and solve problems along the way.
